Achieving space situational awareness requires, at a minimum, the identification, characterization, and tracking of space objects. Leveraging the resultant space object data for purposes such as hostile threat assessment, object identification, and conjunction assessment presents major challenges. This is in part because in characterizing space objects we reference a variety of identifiers, components, subsystems, capabilities, vulnerabilities, origins, missions, orbital elements, patterns of life, operational processes, operational statuses, and so forth, which tend to be defined in highly heterogeneous and sometimes inconsistent (...) ways. The Space Domain Ontologies are designed to provide a consensus-based realist framework for formulating such characterizations in a way that is both consistent and computable. Space object data are aligned with classes and relations in a suite of ontologies built around the existing Space Object Ontology. They are stored in a dynamically updated Resource Description Framework triple store, which can be queried to support space situational awareness and the needs of spacecraft operators and analysts. This paper provides an overview of the Space Domain Ontologies and their development and use. It presents the motivation for and advantages of the Space Domain Ontologies, including the benefits they provide for enhancing and maintaining long-term space situational awareness. (shrink)

There is the world of ideas and the world of practice; the French are often for sup pressing the one and the English the other; but neither is to be suppressed. -Matthew Arnold The Function of Criticism at the Present Time From its inception, bioethics has confronted the need to reconcile theory and practice. At first the confrontation was purely intellectual, as writers on ethical theory (within phi losophy, theology, or other humanistic disciplines) turned their attention to topics from the (...) world of medical practice. Recently the confrontation has grown more intense. The ap pointment of clinical ethicists in hospitals and other health care settings is an accelerating trend in North America. Concomitantly, those institutions involved in training peo ple in clinical ethics have added organized exposure to the world of practice, in the form of placement requirements, to the normal academic course load. In common with other dis ciplines, bioethics has begun to see clinical training as a con dition of didactic theory and apprenticeship. (shrink)

In a naïve realist approach to reading an ontology off the models of a physical theory, the invariance of a given theory under permutations of its property-bearing objects entails the existence of distinct possible worlds from amongst which the theory cannot choose. A brand of Ontic Structural Realism attempts to avoid this consequence by denying that objects possess primitive identity, and thus worlds with property values permuted amongst those objects are really one and the same world. Assuming that any successful (...) ontology of objects is able to describe a universe containing a determinate number of them, I argue that no version of OSR which both retains objects and understands ‘structure’ in terms of relations can be successful. This follows from the fact that no set of relational facts is sufficient to fix the cardinality of the collection of objects implied by those facts. More broadly, I offer reasons to believe that no version of OSR is compatible with the existence of objects, no matter how ontologically derivative they are taken to be. Any such account would have to attribute a definite cardinality to a collection of objects while denying that those objects are possessed of a primitive identity. With no compelling reason to abandon the classical conception of cardinality, such an attribution is incoherent. (shrink)

ABSTRACTPrevious research has demonstrated that anxious individuals attend to negative emotional information at the expense of other information. This is commonly referred to as attentional bias. The field has historically conceived of this process as relatively static; however, research by [Zvielli, A., Bernstein, A., & Koster, E. H. W.. Dynamics of attentional bias to threat in anxious adults: Bias towards and/or away? PLoS ONE, 9, e104025; Zvielli, A., Bernstein, A., & Koster, E. H. W.. Temporal dynamics of attentional bias. Clinical (...) Psychological Science, 3, 772–788.], and others, challenges this assumption by demonstrating considerable temporal variability in attentional bias amongst anxious individuals. Still, the mechanisms driving these temporal dynamics are less well known. Using a modified dot-probe task, the present study examined the impact of two relevant contextual variables- affective valence and trial repetition. Affective context was instantiated by the presentation of... (shrink)

A major barrier to recombination between bacterial species lies in the mismatch repair system, a complex of proteins that has evolved to proof‐read freshly replicated DNA. It now appears that a second system, involving an inducible DNA recombination, repair and mutagenesis pathway, also regulates interspecies recombination, but in a positive way, being required for recombination between Escherichia coli and Salmonella typhimurium(1). Thus the rate at which newly emerging species of bacteria diverge can be seen as a balance between a permissive (...) state associated with inducible repair and recombination, and the proof‐reading of intermediates in the recombination pathway by the mismatch correction system. (shrink)

I introduce a new method for validating models—including stochastic models—that gets at the reliability of a model’s predictions under intervention or manipulation of its inputs and not merely at its predictive reliability under passive observation. The method is derived from philosophical work on natural kinds, and turns on comparing the dynamical symmetries of a model with those of its target, where dynamical symmetries are interventions on model variables that commute with time evolution. I demonstrate that this method succeeds in testing (...) aspects of model validity for which few other tools exist. (shrink)

There are several facets of second-person neuroscience which can benefit from comparisons with animal behavioral neuroscience studies. This commentary addresses the challenges involved in obtaining quantitative data from second-person techniques, the role of stress in inducing robust responses, the use of interactive functional magnetic resonance imaging (fMRI), and the value of applying interactive methods to studies of aggression and depression.

Aristotle’s account of voluntariness (to hekousion) lacks a sufficiently precise positive definition of ‘voluntary’. This is a problem: in Aristotle’s ethics, voluntariness is an important and unifying joint between psychological (character) and practical matters (action). I contend that Aristotle implicitly defines voluntariness as positive causal relation to an agent’s desire, where one’s character is the state of one’s faculty of desire. Since desires always have particular ends (final causes), a voluntary action is one which originates in the agent’s desire for (...) that action’s end. Using this interpretation, I answer questions about ‘mixed’ actions, culpable ignorance, and non-voluntariness. Without this interpretation, these questions cannot be systematically answered. (shrink)

Framed as a critique of David Hume’s analysis of miracles, Peirce offers a sustained argument against an approach to historical inference he calls the “Method of Balancing Likelihoods‘ (MBL). In MBL the posterior probability that a disputed historical event has occurred is computed on the basis of the prior probability of that event occurring and the probability that each purported witness of the event has given accurate testimony. Peirce’s critique of this method is hierarchical: he denies that an objective probability (...) obtains for the truthfulness of witness testimony. Conceding this point, he asserts that, even if such objective probabilities exist, it is implausible to believe that witnesses are independent of one another. Conceding the first two points, Peirce argues that the very sampling process inherent to history necessarily introduces a strong probabilistic dependence that makes MBL unreliable. Finally, irrespective of the success of his first three criticisms, Peirce argues that MBL can be shown by empirical means to fail as a reliable method of inference. I reconstruct this hierarchical critique from a handful of Peirce’s manuscripts, and emphasize its continuing relevance for modern accounts of judgment aggregation. (shrink)

We suggest that the inclusion of anxiety, as one relevant mood factor, could enhance the implementation of the integrative memory model in research and the clinic. The role of anxiety in Alzheimer's disease neuroanatomy, symptomology, and progression is used as an example. Customization of the integrative memory model can establish strong foundations for pathology-specific models of memory deficits, enhancing the development of precision medicine applications.

Increasing attention has been paid to Platonism in Rousseau’s moral and political thought; however, there has been incomplete consideration of his annotated Platonis Operum – a Ficino Latin translation. Addressing this lacuna, the article details Rousseau’s study of Plato’s works. It can be shown that Rousseau’s reading of Plato commenced no earlier than the summer of 1737 during his residence at Les Charmettes. At this time, Rousseau had been considering a set of largely seventeenth-century philosophical texts, which allows contextualisation of (...) his encounter with Plato and the themes he drew upon. As part of a cluster of intellectual activities, Rousseau canvassed Platonic tropes of sublimated Eros and disinterestedness. Meanwhile, he conceptualised ideas as objects of the understanding typical of Locke and a seventeenth-century discourse known as the ‘way of ideas’. These interests challenge existing accounts of Rousseau’s Platonism; moreover, Rousseau’s mature works attempt to reconcile Platonic beliefs on sublime love with ideas conceptualised under a demi-Lockean episteme. (shrink)

The use of the Law of Likelihood (LL) as a general tool for assessing rival hypotheses has been criticized for its ambiguous treatment of background information. The LL endorses radically different answers depending on what information is designated as background versus evidence. I argue that once one distinguishes between two questions about evidentiary support, the ambiguity vanishes. I demonstrate this resolution by applying it to a debate over the status of the ‘fine-tuning argument’.

Sex differences in reproductive strategy and the sexual division of labor resulted in selection for and maintenance of sexual dimorphism across a wide range of characteristics, including body size, hormonal physiology, behavior, and perhaps spatial abilities. In laboratory tasks among undergraduates there is a general male advantage for navigational and mental-rotation tasks, whereas studies find female advantage for remembering item locations in complex arrays and the locations of plant foods. Adaptive explanations of sex differences in these spatial abilities have focused (...) on patterns of differential mate search and routine participation in distinct subsistence behaviors. The few studies to date of spatial ability in nonindustrial populations practicing subsistence lifestyles, or across a wider age range, find inconsistent results. Here we examine sex- and age-based variation in one kind of spatial ability related to navigation, dead-reckoning, among Tsimane forager horticulturalists living in lowland Bolivia. Seventy-three participants (38 male) aged 6–82 years pointed a handheld global positioning system (GPS) unit toward the two nearest communities and the more distant market town. We find no evidence of sex differences in dead reckoning (p = 0.47), nor do we find any evidence of age-related decline in dead-reckoning accuracy (p = 0.28). Participants were significantly more accurate at pointing toward the market town than toward the two nearest villages despite its being significantly farther away than the two nearest communities. Although Tsimane do show sexual dimorphism in foraging tasks, Tsimane women have extensive daily and lifetime travel, and the local environment lacks directional cues that typically enhance male navigation. This study raises the possibility that greater similarity in mobility patterns because of overlapping subsistence strategies and activities may result in convergence of some male and female navigation abilities. (shrink)

The authenticity of the Additamentum Aldinum (Sil. Pun. 8.144–223) has long been a matter of debate. While many scholars have expressed doubts that it is by Silius and suggest rather that it is from the hands of a skilful humanist, it has not, up to this time, been possible to provide solid evidence to support their intuition. This paper not only re-examines the standard arguments for and against authenticity but brings the latest computational stylometric techniques to bear on the question. (...) These analyses reveal that the style of the Additamentum differs in statistically significant terms from the rest of Silius’ Punica.1. (shrink)

Middle childhood, the period from 6 to 12 years of age, is defined socially by increasing autonomy and emotional regulation, somatically by the development of anatomical structures for subsistence, and endocrinologically by adrenarche, the adrenal production of dehydroepiandrosterone (DHEA). Here I suggest that DHEA plays a key role in the coordinated development of the brain and body beginning with middle childhood, via energetic allocation. I argue that with adrenarche, increasing levels of circulating DHEA act to down-regulate the release of glucose (...) into circulation and hence limit the supply of glucose which is needed by the brain for synaptogenesis. Furthermore, I suggest the antioxidant properties of DHEA may be important in maintaining synaptic plasticity throughout middle childhood within slow-developing areas of the cortex, including the insula, thamalus, and anterior cingulate cortex. In addition, DHEA may play a role in the development of body odor as a reliable social signal of behavioral changes associated with middle childhood. (shrink)

Parallel moral luck problems exist in three different normative domains: criminal law, tort law, and conventional moral thinking. In all three, the normative status of an actor’s conduct seems to depend on matters beyond the actor’s control. Criminal law has historically imposed greater punishment on the murderer who kills his intended victim than on the identically behaved would-be murderer whose shot fortuitously misses. Tort law imposes liability on the negligent driver who injures someone, but no liability if, through good fortune, (...) the negligence injures no one. And, as BernardWilliams and Thomas Nagel have famously argued, conventional moral thinking often attributes greater blame to an actor for wrongful conduct if that conduct ripens into a terrible event than if it fortuitously causes no harm at all. This Article distinguishes two different dimensions of responsibility and then uses this distinction to explain the problem in all three areas. One dimension is called "fault-expressing responsibility": it is a matter of the degree to which one’s acts constitute conduct that can express one’s character or faultiness. A second dimension of responsibility is called "agency-linking responsibility." In this dimension, the degree to which a person is responsible for some event is dependent upon whether that event is an action of that person. Responsibility can differ in the agency-linking dimension even if it remains the same in the fault-expressing dimension. (shrink)

Background To identify and to summarize challenges related to the informed consent process for research completed during humanitarian emergencies. Methods Using relevant search terms, a search of 5 databases was completed, without language, date, or study type restriction. Studies were screened for inclusion, with eligible studies being those that were relevant to the informed consent process for research studies completed in humanitarian emergencies. A Grounded Theory Analysis was completed to identify themes and subthemes. Results Review identified 30 relevant studies. We (...) identified 11 challenges (lack of trust, therapeutic misconception, reduced capacity, security and privacy concerns, harmful research, power differential, literacy, language/local and cultural context, researcher burden and re-evaluation of ongoing trials) and 7 strategies (engage local research communities, use alternative to standard written consent process, modify traditional process of research ethics board review, dynamic consent, training of research staff, mandating transparency of commercial interests, and mandating reporting of informed consent process in all publications) to confront the challenges. These challenges and strategies were unique to the informed consent process in research conducted during humanitarian emergencies. Conclusions This scoping review identified an evidence-based guide for researchers and research ethics boards to perform ethical informed consent procedures in humanitarian emergencies. Trial Registration This trial was not registered as scoping reviews can not be registered as per updated PROSPERO guidelines. (shrink)

Scientists routinely solve the problem of supplementing one’s store of variables with new theoretical posits that can explain the previously inexplicable. The banality of success at this task obscures a remarkable fact. Generating hypotheses that contain novel variables and accurately project over a limited amount of additional data is so difficult—the space of possibilities so vast—that succeeding through guesswork is overwhelmingly unlikely despite a very large number of attempts. And yet scientists do generate hypotheses of this sort in very few (...) tries. I argue that this poses a dilemma: either the long history of scientific success is a miracle, or there exists at least one method or algorithm for generating novel hypotheses with at least limited projectibility on the basis of what’s available to the scientist at a time, namely a set of observations, the history of past conjectures, and some prior theoretical commitments. In other words, either ordinary scientific success is miraculous or there exists a logic of discovery at the heart of actual scientific method. (shrink)

One implication of Bell’s theorem is that there cannot in general be hidden variable models for quantum mechanics that both are noncontextual and retain the structure of a classical probability space. Thus, some hidden variable programs aim to retain noncontextuality at the cost of using a generalization of the Kolmogorov probability axioms. We generalize a theorem of Feintzeig to show that such programs are committed to the existence of a finite null cover for some quantum mechanical experiments, i.e., a finite (...) collection of probability zero events whose disjunction exhausts the space of experimental possibilities. (shrink)

I introduce a thin concept of ad hoc identity -- distinct from metaphysical accounts of either relative identity or absolute identity -- and an equally thin account of concepts and their content. According to the latter minimalist view of concepts, the content of a concept has behavioral consequences, and so content can be bounded if not determined by appeal to linguistic and psychological evidence. In the case of counting practices, this evidence suggests that the number concept depends on a notion (...) of identity at least as strong as ad hoc identity. In the context of nonrelativistic QM in particular, all of the counting procedures appealed to in the existing literature on nonindividuality are shown to involve ad hoc identity. I then show that Goyal Complementarity and the associated derivation of a strong symmetrization principle in QM can be understood in terms ad hoc identity. Specifically, persistence and non-persistence models of quantum processes are seen to be complementary in the sense that they involve two relations of ad hoc identity that occasionally overlap in empirically meaningful ways. Finally, I attempt to draw out consequences for theories of nonindividuality from the above conceptual analysis. The upshot is that counting and definite cardinality are incompatible with nonindividuality, and that none of the counting procedures cited for quantum phenomena offer positive support for an interpretation in terms of nonindividuals. (shrink)

The South Korean elite sport system is facing a wide range of problems that account for the high dropout rate among college student-athletes. However, research on dropout rates of student-athletes is so far been limited, which amplifies the actual voices of this group, their dropout experiences, and their challenges, while they were in the career transition process. Therefore, this study used a critical phenomenological approach as a primary methodological lens to gather information on 15 formal Korean male college student-athletes on (...) dropping out of team sports, exploring their life challenges during their career transitions out of the sport. The result showed two main thematic categories with sub-themes, which include factors affecting burning out and terminating athletic careers: injury and failure of rehabilitation and bullying and abandonment; and factors hindering post-retirement career advancement: prejudice and exclusion and absence of mentors and counselors. This study used Social Cognitive Career Theory to explore the participants' progression through specific interventions that engage and empower. Overall, the current study calls upon researchers, counselors, and administrators to continue exploring advocacy efforts with this population to alter policy and practice. (shrink)

The Patient Self Determination Act of 1991 brought much needed attention to the importance of advance care planning and surrogate decision-making. The purpose of this law is to ensure that a patient’s preferences for medical care are recognized and promoted, even if the patient loses decision-making capacity. In general, patients are presumed to have DMC. A patient’s DMC may come under question when distortions in thinking and understanding due to illness, delirium, depression or other psychiatric symptoms are identified or suspected. (...) Physicians and other healthcare professionals working in hospital settings where medical illness is frequently comorbid with depression, adjustment disorders, demoralization and suicidal ideation, can expect to encounter ethical tension when medically sick patients who are also depressed or suicidal request do not resuscitate orders. (shrink)

In addition to considering sociocultural, political, economic, and ethical factors, effectively engaging socioscientific issues requires that students understand and apply scientific explanations and the nature of science. Promoting such understandings can be achieved through immersing students in authentic real-world contexts where the SSI impacts occur and teaching those students about how scientists comprehend, research, and debate those SSI. This triangulated mixed-methods investigation explored how 60 secondary students’ trophic cascade explanations changed through their experiencing place-based SSI instruction focused on the Yellowstone (...) wolf reintroduction, including scientists’ work and debates regarding that issue. Furthermore, this investigation determined the association between the students’ post place-based SSI instruction trophic cascade explanations and NOS views. Findings from this investigation demonstrate that through the place-based SSI instruction students’ trophic cascade explanations became significantly more accurate and complex and included more ecological causal mechanisms. Also, significant and moderate to moderately large correlations were found between the accuracy and contextualization of students’ post place-based SSI instruction NOS views and the complexity of their trophic cascade explanations. Empirical substantiation of the association between the complexity of students’ scientific explanations and their NOS views responds to an understudied area in the science education research. It also encourages the consideration of several implications, drawn from this investigation’s findings and others’ prior work, which include the need for NOS to be forefront alongside and in connection with science content in curricular standards and through instruction focused on relevant and authentic place-based SSI. (shrink)